An Efficient and Practical Construction of S−N Bond from Aryl Thioureas and Amines under Metal‐Free Conditions

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A series of sulfenamides was received efficiently from aryl thioureas and amines (mainly secondary amines) by way of cross dehydrogenative coupling reaction (CDC) in the existence of phenyliodine(III) diacetate. The protocol features very easily available starting materials, simple and odorless performance, moderate response situations, superior yields, and a wide substrate scope, illustrating its synthetic price for the synthesis of various biologically or pharmaceutically lively compounds.

Summary

An efficient and sensible design of S−N bond from aryl thioureas and amines below moderate and metallic-free conditions is documented. A sequence of sulfenamides was obtained smoothly from aryl thioureas and amines (mainly secondary amines) as a result of cross dehydrogenation coupling response (CDC) in the presence of phenyliodine(III) diacetate. The protocol attributes very easily accessible starting off materials, simple and odorless functionality, moderate response ailments, great yields, and a wide substrate scope, illustrating its artificial worth for the synthesis of various biologically or pharmaceutically relevant compounds.

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