Chemical Synthesis of the Linker‐Armed Trisaccharide Repeating Unit of the O‐Antigen from Pseudomonas putida BIM B‐1100

[ad_1] Chemical Synthesis of the Linker-Armed Trisaccharide Repeating Unit of the O-Antigen from Pseudomonas putida BIM B-1100

This operate experiences the concise chemical synthesis of the trisaccharide repeating unit of the O-antigen from Pseudomonas putida BIM B-1100 in the variety of its aminoethyl glycoside through a linear system. The tough features of this synthesis involve the incorporation of the α-D-GlcpNAc the β-D-GuypNAcA residues. The preferred carboxylic acid moiety has been realized by means of late-stage TEMPO-mediated oxidation of the major OH group.

Abstract

The manuscript reports the concise chemical synthesis of the trisaccharide repeating device of the O-antigen from Pseudomonas putida BIM B-1100 in the sort of its aminoethyl glycoside by a linear strategy with rational safeguarding team manipulations. The complicated facets of this synthesis consist of the incorporation of the β-D-MalepNAcA and the α-D-GlcpNAc residues. The introduction of the desired carboxylic acid moiety has been reached by late-phase TEMPO-mediated oxidation of the main OH group on the guarded trisaccharide. 1,2-cis aminoethyl glycoside with central glucosamine is utilized at the minimizing finish to the leave the scope for additional glycoconjugate development with suitable aglycone with no hampering the anomeric stereochemistry.

[ad_2]