Jared Leto in 'Dallas Buyers Club' (2013) - Leto won an Academy Award for Best Supporting Actor for his role as trans woman Rayon.
Julie Andrews in 'Victor/Victoria' (1982) - Julie Andrews plays a woman who pretends to be a man impersonating a woman.
Elle Fanning in '3 Generations' (2015) - The actress plays a teen called Ray, who decides to transition. Naomi Watts stars as his mother, and Susan Sarandon as his grandmother.
Glenn Close in 'Albert Nobbs' (2011) - The veteran actress plays the titular Albert Nobbs in this film set in late-19th-century Ireland.
Linda Hunt in 'The Year of Living Dangerously' (1982) - Linda Hunt plays a Chinese-American photographer with dwarfism in this Australian movie.
Tilda Swinton in 'Orlando' (1992) - Swinton plays an androgynous young nobleman, who later in the movie becomes a woman.
John Travolta in 'Hairspray' (2007) - This remake of the 1988 John Waters' movie stars John Travolta as the protagonist's mom, Edna Turnblad.
Cillian Murphy in 'Breakfast on Pluto' (2005) - The actor plays a trans woman named "Kitten" Braden, who moves from Ireland to London in the 1970s.
Cate Blanchett in 'I'm Not There' (2007) - The actress plays iconic singer-songwriter Bob Dylan in this film. She was even nominated for the Oscar for Best Supporting Actress for the role.
Rupert Everett in 'St. Trinian's' (2007) - St. Trinian's, a school for poorly behaved young women, is run by headmistress Camilla Dagey Fritton, played by Rupert Everett.