Barney Stinson and Robin Scherbatsky: Played by Neil Patrick Harris and Cobie Smulders, this is likely the couple with the least chemistry in 'How I Met Your Mother.
Lady Sarah Ashley and Drover: Australian actors Nicole Kidman and Hugh Jackman aren't the dream couple we'd like them to be in 'Australia' (2008).
Johnny and Lisa: Tommy Wiseau and Juliette Danielle play this odd couple in cult classic 'The Room' (2003).
Belle and Beast: Beauty and the Beast' (2017) is a beautiful story, but less beautiful is the on-screen chemistry between Emma Watson and Dan Stevens.
Josh and Cornelia Srebnick: Ben Stiller has had many love interests in movies, but it's safe to say that Naomi Watts in 'While We're Young.
Abigail "Abby" Richter and Mike Chadway: Katherine Heigl and Gerard Butler wouldn't make a great couple.
Katniss Everdeen and Peeta Mellark: Jennifer Lawrence and Josh Hutcherson make an odd couple in 'The Hunger Games' (2012).
Andrea "Andy" Sachs and Nate Cooper: Anne Hathaway and Adrian Grenier play this couple in 'The Devil Wears Prada' (2006).
Bruce Wayne/Batman and Rachel Dawes: Katie Holmes and Christian Bale are yet another on-screen couple who don't seem to belong together.
Longfellow Deeds and Babe Bennett: Winona Ryder comes next as one of Adam Sandler's most uncomfortable leading ladies.