Scarlett Johansson: In 2018, Scarlett Johansson was cast to play a trans man in the movie 'Rub & Tug.
Julianne Moore: In 2010, Julianne Moore, who is straight, played a lesbian woman in the Oscar-nominated film 'The Kids Are All Right.' In an interview for Variety.
Mahershala Ali: The 2018 film 'Green Book' won Best Picture at the Oscars, and earned Mahershala Ali Best Supporting Actor.
Sarah Paulson: On top of gaining 30 lbs (13 kg) Sarah Paulson received backlash for wearing padding to play Linda Tripp.
Hank Azaria: Hank Azaria was the voice of the Indian character Apu on 'The Simpsons' for over 20 years.
Halle Berry: The Oscar-winner is another cisgender actress who caught fire when she announced she was considering a role as a trans man.
Paul Newman (1925-2008): Before becoming one of the biggest stars in Hollywood, Paul Newman was just another working actor.
Anne Hathaway: Anne Hathaway starred as the Grand High Witch in the 2020 remake of 'The Witches.
Rooney Mara: Rooney Mara was cast in the 2015 remake of 'Peter Pan,' called 'Pan.' She played the role of Tiger Lily, a Native American character.
Emma Stone: The white actress Emma Stone played a character of Chinese and Hawaiian descent.