Catalyst‐ and Metal‐Free Photo‐Oxidative Coupling of Thiols with BrCCl3

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A photo-oxidative homo-coupling of thiol was promoted by BrCCl₃ in THF. This catalyst- and steel-cost-free technique was used to synthesize disulfides less than moderate problems. The clean up reaction minimized the risk of contamination of the item.

Abstract

This paper reported a catalyst- and metal-free of charge approach to build disulfide bond with BrCCl₃ beneath mild irradiation. This thoroughly clean and mild response promoted the oxidative coupling of thiols with extensive substrate scope, and is relevant to benzylic, aryl and aliphatic thiols, in particular cysteine spinoff. The disulfides were obtained in substantial yields up to 98�

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