cis‐Aziridine Synthon Based Synthetic Investigation for Tamiflu Employing Horner‐Wadsworth‐Emmons Reaction

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Synthetic investigation to realize a novel intermediate of tamiflu by applying cis -aziridine as a chiral building block which is easily synthesized from ᴅ-mannitol as a renewable commencing materials has been introduced. The current method makes use of the intramolecular Horner-Wadsworth-Emmons reaction as the crucial phase for the synthesis of tamiflu. On the other hand, diene made up of allylic aziridine framework is observed to be inefficient to furnish the six-membered core skeleton of tamiflu through ring-closing metathesis reaction.

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